A ‘wearable’ brain scanner for studies of human interaction, dementia, movement disorders, and more

Julie Brefczynski-Lewis, a neuroscientist at West Virginia University, places a helmet-like PET scanner on a research subject. The mobile scanner—designed for studies of human interaction, movement disorders, and more—is based on a scanner developed at Brookhaven Lab for brain-imaging studies in freely moving animals. Credit: US Department of Energy

Patients undergoing a positron emission tomography (PET) scan in today’s bulky, donut-shaped machines must lie completely still. Because of this, scientists cannot use the scanners to unearth links between movement and brain activity. What goes on up there when we nod in agreement or shake hands? How are the brains of people struggling to walk after a stroke different from those who can?

To tackle questions like these, Julie Brefczynski-Lewis, a neuroscientist at West Virginia University (WVU), has partnered with Stan Majewski, a physicist at WVU and now at the University of Virginia, to develop a miniaturized PET brain scanner. The scanner can be “worn” like a helmet, allowing research subjects to stand and make movements as the device scans. This Ambulatory Microdose Positron Emission Tomography (AMPET) scanner could launch new psychological and clinical studies on how the brain functions when affected by diseases from epilepsy to addiction, and during ordinary and dysfunctional social interactions.

“There are so many possibilities,” said Brefczynski-Lewis, “Scientists could use AMPET to study Alzheimer’s or traumatic brain injuries, or even our sense of balance. We want to push the limits of imaging mobility with this device.”

The idea was sparked by a scanner developed for studying rats, a project started in 2002 at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory. Majewski, a high-energy physicist by…

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